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Am J Physiol Cell Physiol, 307:C1130-1141

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Until recently, therapeutic strategies for people with obesity were of limited efficacy 2 , with the main strategies for weight loss focused on lifestyle interventions, including diet and exercise 3

The country's well-developed private healthcare sector demonstrates strong uptake of obesity pharmacotherapy among patients willing to bear treatment costs

Intermittent fasting may enhance calorie deficit, which amplifies tirzepatide's weight loss effects, but it does not improve the medication's biological mechanism

Disclosure DZIC has received honoraria from Boehringer Ingelheim-Eli Lilly, Merck, AstraZeneca, Sanofi, Mitsubishi-Tanabe, AbbVie, Janssen, Bayer, Prometic, Bristol-Myers Squibb, Maze, CSL-Behring, and Novo Nordisk, and has received operational funding for clinical trials from Boehringer Ingelheim-Eli Lilly, Merck, Janssen, Sanofi, AstraZeneca, and Novo Nordisk