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Preclinical studies have demonstrated that GLP-1R agonists can reduce the accumulation of amyloid plaques, a hallmark of Alzheimer's disease, and improve synaptic function

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However, it can cause steatorrhea, resulting in fat-soluble vitamin deficiency, and can even cause liver damage

[PubMed] [Google Scholar] 818.Krass M., Volke A., Runkorg K., Wegener G., Lund S., Abildgaard A

Long-term efficacy and safety of linagliptin in patients with type 2 diabetes and severe renal impairment: a 1-year, randomized, double-blind, placebo-controlled study