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For this reason, bacteriostatic water-diluted medications should be used during pregnancy only if clearly needed and if the potential benefit justifies any potential risk to the fetus

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Notably, despite the induction of pain following acute TRPV1 activation by agonists such as capsaicin, prolonged/repeated stimulation has been shown to lead to receptor desensitization with analgesic effects (Gao et al., 2024)

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