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Moreover, due to these substitutions, semaglutide has a prolonged half-life of approximately 168 h, which is impressive given the knowledge that native GLP-1 has a half-life of 2 min, in comparison [98, 99]

Some preliminary evidence suggests that meal distribution throughout the day may influence metabolic responses, though direct effects on GLP-1 secretion specifically require further research

Acute pancreatitis remains a rare but serious signal under continued surveillance

Stomach problems, sometimes severe, have been reported in people who use Wegovy

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