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In animal studies, SGLT2 inhibitors were generally safe during the first trimester but exposure during postnatal day 21 to 90 in juvenile rats, a period coinciding with the late second and third trimester of human renal development, caused dilatation of the renal pelvis and tubules

However, for most, the most prominent results start to shine within approximately 12 weeks

Many clinicians and researchers extend the time at each dose level if side effects are bothersome

Endocrine Reviews, 43(5), 763793

Results are most pronounced in patients who use phentermine as part of a comprehensive program that includes dietary changes and increased physical activity

23 Still, the use of pharmacological antiobesity agents is considered experimental in women with PCOS when aimed at enhancing fertility, 24 thus opening new venues for clinical research on restoring fertility in obese PCOS patients