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10.7759/cureus.40877 [DOI] [PMC free article] [PubMed] [Google Scholar] 73.Van de Velde F, Lapauw B

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Of those molecules that appear to be progressing well, Dapagliflozin, developed by Bristol-Myers Squibb and AstraZeneca Ltd, is currently in Phase 3 and is an inhibitor of SGLT2, which in turn impedes glucose reabsorption in the proximal tubule leading to glucosuria and plasma glucose reduction (Figure 1)