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Izervay is a PEGylated oligonucleotide that works by targeting and disabling the C5 complement protein, thus addressing an underlying cause of age-related macular degeneration (AMD)

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Given the high incidence of vomiting, the author suggested prophylactic administration of antiemetics

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Adequate hydration, fiber intake, and movement help mitigate this

In people with established CVD, a GLP-1 RA with proven benefit should be used to reduce MACE, or an SGLT2i with proven benefit should be used to reduce MACE and HF and improve kidney outcomes