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The rapid global adoption of GLP-1 based therapies, developed for diabetes and now also used for weight management, has reshaped the pharma landscape

GLP-1R agonist 2 (compound 2) is an effective GLP-1R agonist that exerts its activating effect by forming hydrogen bonds with the Tyr42, Cys71, and Ser84 residues of GLP-1R

Type 2 diabetes mellitus (T2DM) is a complex disease that has become a major global health concern

GLP-1 monoclonal antibody, clone 77/31B, exhibits an IgG1 isotype and recognizes GLP-1(1-36) (Glucagon-like peptide-1) for human epitopes

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Methods We conducted a systematic review of studies from PubMed, Embase, and Cochrane databases (until November 2024), as well as relevant abstracts from Digestive Disease Week (DDW) 2024 and American College of Gastroenterology (ACG) 2024 to assess the impact of GLP-1 receptor agonists (GLP-1 RAs) on EGD