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Patient Selection Criteria and Clinical Eligibility Assessment Not every patient benefits equally from dual-therapy approaches

In obesity clinical trials, patients achieved approximately 15-21% weight loss over 72 weeks, with somewhat smaller weight reductions typically seen in diabetes trials

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Weight-bearing loads from body weight contribute to bone maintenance, and losing significant weight removes some of that mechanical stimulus

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(1) By binding to GLP-1 receptors, Semaglutide: Enhances insulin secretion Suppresses glucagon release (which reduces blood sugar levels) Delays gastric emptying Promotes satiety These combined actions have been shown to help regulate blood sugar levels and reduce appetite
