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The Watchman Device is a left atrial appendage closure device used to reduce stroke risk in patients with AFib who cannot take blood thinners

25 Owing to the excretion of glucose via the urinary tract, patients taking SGLT2 inhibitors may be predisposed to urinary tract infections (UTIs)

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While the resolution of the cryo-EM map does not allow us to clearly resolve the interactions in this region, our model suggests that the exposure of the carbonyl oxygens in the backbone of Pro 6.47b -Leu-Leu 6.49b enables interactions with polar residues in TM3,5,7 that stabilize the outwards opening of the cytoplasmic half of TM6

Funding This study was supported by a grant from The Universiti Kebangsaan Malaysia Medical Centre (GUP-2017-066) and a grant from the Malaysian Endocrine & Metabolic Society (L12-MEMS6)