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107 Interestingly, only an estimated 15% of the active GLP-1 reaches the portal vein before the liver, due to the rapid inactivation through DPP-IV

10.1038/nrn2867 [DOI] [PubMed] [Google Scholar] Collins S

Site-specific pegylated Exendin-4 modified with a high molecular weight trimeric PEG reduces steric hindrance and increases type 2 antidiabetic therapeutic effects

If these side effects persist, talk to your provider about other options within your treatment plan

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