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Subcellular cAMP distribution and insulin secretion are not enhanced by fast-internalizing GLP-1R agonists in -cells

liraglutide and semaglutide which use a synthetic version of human GLP-1

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Estimates of Diabetes and Its Burden in the United States

In the central nervous system (CNS), GLP-1 and GLP-1R agonists are diffused into the cerebrospinal fluid (CSF) and the brain as demonstrated in rodent models (Wang et al., 2015), and increased GLP-1 concentration in the brain is thought to influence brain function in the hippocampus (Kastin et al., 2002

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By reducing neuroinflammation from both the metabolic and the alcohol-related sides, these medications may break the self-reinforcing cycle where inflammation drives consumption, and consumption drives more inflammation