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[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 inflammasome

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Since GLP-1R activation results in increased cAMP levels [104,111] and glucocorticoids also increase the cAMP level in mice and humans in -cells [112], it could speculate that the increase in cAMP might modulate the hypothalamic TREK channels and make hypothalamic cells more excitable