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Conclusion In this NMA, tirzepatide 10 and 15 mg were associated with improved efficacy versus liraglutide, improved or comparable efficacy versus semaglutide, and all interventions had a generally comparable safety profile for achieving weight reduction and reducing cardiometabolic risk factors among patients with obesity or overweight.

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A pharmacist holds a box of Novo Nordisk A/S Ozempic brand semaglutide medication at a pharmacy in Provo, Utah, Nov
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