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doi: 10.1016/j.diabres.2015.07.015 4 SunFWuSWangJGuoSChaiSYangZet al

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Nov 2023 - The FDA's approval of Eli Lillys Zepbound (tirzepatide) represents a significant advancement in obesity treatment, as it uniquely targets both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors

In adipose tissue, GLP-1 receptors are directly expressed and activation impacts apoptosis and preadipocyte proliferation, as well as fat deposition through regulation of lipolysis, fatty acid oxidation, and adipocyte differentiation
