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But as science relentlessly marches forward, were bound to encounter newand potentially betterdrugs

Mean percent body weight change at 80 weeks, by dose: Retatrutide 4 mg : 19.0% (47.2 lbs) Retatrutide 9 mg : 25.9% (64.4 lbs) Retatrutide 12 mg : 28.3% (70.3 lbs) Placebo : 2.2% (5.5 lbs) Responder rates at the 12 mg dose are the more interesting number for clinicians

They're so convenient and curb cravings

11 There are several possible reasons for this, which could span from clinical inertia, a sense that prescribing these drugs require endocrinologist expertise, or to the subcutaneous mode of administration of most drugs in this class

While earlier medications only targeted the GLP-1 receptor, tirzepatide was designed to target both GLP-1 and GIP receptors

Preclinical studies and a small number of early clinical trials suggest potential benefits in reducing nicotine cravings and limiting post-cessation weight gain