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Activation of GLP-1R also triggers the PI3K/Akt signaling pathway via the subunits of G proteins, thereby promoting -cell viability and replicative capacity ( 2.2 Inflammation and immune modulation Recent preclinical studies have demonstrated its bidirectional immunomodulatory effects, including improvement of organ dysfunction, regulation of immune responses, and mitigation of sepsis-associated cytokine storms, mediated through anti-inflammatory and anti-apoptotic pathways

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[DOI] [PMC free article] [PubMed] [Google Scholar] 190.Balachandra S., Syed R., Song Z., Kasmirski J., Gillis A., Fazendin J., Lindeman B., Chen H

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Fuchs Andersen C, Omar M, Glenthoj A, El Fassi D, Moller HJ, Lindholm Kurtzhals JA, Styrishave B, Kistorp C, Tuxen C, Poulsen MK, Faber J, Kober L, Gustafsson F, Moller JE, Schou M, Jensen J