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Clinical trials have shown body weight reductions of 15 to 20% in some participants, which explains why these medications have exploded in popularity beyond diabetes treatment (Wilding et al., 2021, New England Journal of Medicine)

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Metabolic acidosis is the build-up of acid in body fluid, which can lead to several dangerous medical conditions
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In participants with type 2 diabetes, retatrutide lowered HbA1c by up to 2.02.2% at 3640 weeks across doses, with improvements in fasting glucose, insulin sensitivity, and a high rate of reversion from prediabetes to normoglycemia (up to 72% in relevant cohorts)

Frequently Asked Questions Can GLP-1 agonists reverse leptin resistance
