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Where the GLP-1 MDL stands now As of March 2026, the GLP-1 MDL is in the expert discovery phase

calc: value calculated considering reported mean baseline and mean absolute change

Once-daily liraglutide compared favorably with twice-daily exenatide, with similar improvements in A1C and body weight reductions

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28 , 29 Subgroup analyses from various cardiovascular outcomes trials have also shown that GLP-1 RAs may benefit kidney-related outcomes, including reductions in albuminuria, slower declines in estimated glomerular filtration rate, and a decreased risk of end-stage kidney disease in patients with and without diabetes