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45,46 These results were confirmed by a pooled analysis that demonstrated that the improvement in quality of life and functional capacity may be primarily related to weight loss, and that there were significant declines in HF hospitalisations or urgent visits (8 [1%] versus 30 [5%] patients in the semaglutide and placebo groups, respectively

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The active ingredients (semaglutide, tirzepatide) are FDA-approved drugs, but compounded preparations are legally permissible for patient-specific use under physician supervision