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In addition to these findings on atherosclerotic plaque formation, GLP-1R agonists prevented the increase in plasminogen activator inhibitor type-1 (PAI-1) and vascular cell adhesion molecule-1 (VCAM-1) gene expression in response to TNF- or hyperglycemia in HUVEC through PKA pathway [24],[70]

Belonging to the GLP-1 receptor agonists class, semaglutide works by mimicking the actions of a hormone called glucagon-like peptide-1 (GLP-1)

It may also be prescribed off-label as a weight management drug for people without type 2 diabetes

6 , e009417 (2016)
