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Description
Both the receptor of insulin and IGF-1 belong to the receptor tyrosine kinase family
Exp Clin Endocrinol Diabetes 122(10):608614 Younce CW, Burmeister MA, Ayala JE (2013) Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a
Eliasson, A.-M
The observed protective effects are mediated through multiple molecular mechanisms, including enhanced metabolic regulation, direct anti-proliferative actions, and augmented immune surveillance [16, 17]
In humans, once-weekly subcutaneous dual GLP-1R/GIPR agonist LY3298176 administration obtained greater weight loss and glucose control than dulaglutide, with an acceptable tolerability profile [166]
Sources: GLP-1 Agonists. The Cleveland Clinic.
