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Abdominal obesity increases the risk of insulin resistance, a metabolic syndrome component that precedes the development of type 2 diabetes (T2D)

Back Larsen, PJ, Fledelius, C, Knudsen, LB, Tang-Christensen, M (1 Nov 2001) 'Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats', Diabetes , 50/11, 253039

37 Alongside obesity, GLP1 and GLP1R also directly affect on the hypothalamicpituitarygonadal axis, thus modulating female reproductive function

However, aldosterone secretion is regulated by several factors besides ANG II, including potassium concentration, ACTH, and membrane depolarization of zona glomerulosa cells (93)

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This article will explore the side effect profile of retatrutide based on current clinical trial data and explain why they happen, highlight rare or serious side effects, and provide practical tips for patients and clinicians on monitoring and management