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Titration Phase : After 4 weeks, the dose is increased to 0.5 mg weekly

The anatomical substrate of this functional brain-vascular unit is the blood-brain barrier (BBB) which was described first-hand by Paul Elrich in 1885 (Khatri et al., 2012) and Dyrna et al

In the SURPASS program, gastrointestinal side effects associated with the use of tirzepatide were similar to those observed with semaglutide and GLP1-RA drugs in general, both in terms of frequency and duration [3]

Any perceived benefits would be indirect at best, and patients should not expect these medications to alleviate endometriosis symptoms such as pelvic pain, dysmenorrhea, or dyspareunia

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