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The Numbers And Why Direct Comparison Is Complicated UBT251s Phase 2 results (released today, February 24, 2026): up to 19.7% mean weight loss at 24 weeks in a Chinese population with obesity, from a baseline weight of 92.2 kg

The wrinkle is that this bet has been slower than anyone expected

But eating less also means less protein, fewer vitamins and minerals, and less fluid

10.1056/NEJMoa052187 [EL 1

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Individuals who should not use probiotics without consulting their GP include: Those with severely compromised immune systems (including patients receiving chemotherapy, those with HIV/AIDS, or taking immunosuppressive medications) Patients with central venous catheters or other indwelling medical devices Individuals with short bowel syndrome or intestinal damage People with a history of probiotic-related infections Those with severe acute pancreatitis (where probiotics have been associated with increased mortality in clinical trials) Pregnant and breastfeeding women should discuss probiotic use with their midwife or GP, though many strains are considered safe during pregnancy