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Abstract Glucagon-like peptides (GLP-1 and GLP-2) are two proglucagon-derived intestinal hormones that mediate distinct physiological functions through two related receptors (GLP-1R and GLP-2R) which are important drug targets for metabolic disorders and Crohns disease, respectively
The appetite-suppressing effect of GLP-1 is mediated by its action in the brain, whereas its glucose-lowering effect is mainly attributed to enhancement of glucose-stimulated insulin secretion [74]
Wegovy is approved for weight management and reducing the risk of heart attacks and strokes, while metformin is approved for Type 2 diabetes
Starting July 1, 2026, the Centers for Medicare and Medicaid Services (CMS) will launch a new federal program that gives many Medicare beneficiaries access to GLP-1 medications for weight management for the first time
Table of Contents What Are GLP-1 Inhibitors
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