stalled weight loss on tirzepatide Plateau: Why Stalls Happen and What to Do Weight Loss Plateau on Tirzepatide:

The SURMOUNT-5 trial showed tirzepatide produces about 47% more weight loss than semaglutide on average, which is 20.2% versus 13.7% body weight reduction over 72 weeks

Adjustments may be made based on how the patient tolerates the medication, their appetite, or doctor recommendations

However, the regulatory environment around compounded semaglutide has been evolving - the FDA determined in February 2025 that the branded semaglutide shortage had ended, which has implications for ongoing compounding practices

Taking both medications too close together increases gastrointestinal side effects without providing additional benefit

What Workout Split of Cardio and Resistance Training Gives the Best Fat Loss on a GLP-1 Without Losing Muscle

If you put too much on it at once, things get backed up