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SHP2 in the hypothalamic neuron links LepR signal to MAPK, inducing thermogenesis by controlling sympathetic activity in BAT, and promoting the anorectic effects of leptin [136, 137]

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Invariant natural killer T (iNKT) cells, although constituting less than 1% of all peripheral blood T cells, play a pivotal role in the pathogenesis of inflammatory diseases [56]

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