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Methods Clin

Progress in peptide and protein therapeutics will ultimately depend not on overcoming biology through ever more complex delivery systems, but on aligning development strategies with biological constraints

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These hormones, released post-meal, stimulate insulin secretion, suppress glucagon release, and promote satiety

However, few prospective studies have conducted prespecified, systematic causal pathway analyses linking these metabolic improvements to reproductive endpoints such as ovulation, clinical pregnancy, or live birth rates

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