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Motility issues can happen anywhere from the esophagus, the stomach, small intestine or large intestine

(2017) 6(6):CD012691

Effects of glucose-dependent insulinotropic peptide on osteoclast function

Young adult male patients with childhood-onset IBD have increased risks of compromised cortical and trabecular bone microstructures

They stimulate insulin release, reduce gluconeogenesis, slow down digestion, and give a feeling of satiety

These data suggested that the gut makes a hormone(s) that regulates insulin levels, and they came to be known as incretins which were defined by Creutzfeld as factors that i) are released from gut in response to carbohydrates, ii) stimulate insulin secretion, and iii) act only in the presence of high blood glucose (2)