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Indoleacrylic acid produced by commensal peptostreptococcus species suppresses inflammation

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Importantly, these same probes can be conjugated with therapeutic payloads, including cytotoxic agents, photosensitizers, or therapeutic radionuclides, to allow direct treatment of pathologic foci under imaging guidance [350, 441]

Both types are synthetically manufactured, but newer agents are structurally closer to the hormone naturally found in our bodies