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[33] [34] In 2026, the UK Medicines and Healthcare products Regulatory Agency (MHRA) updated its guidance on GLP-1 medication after an increase in reports to the agency's Yellow Card Scheme of acute pancreatitis, with fatalities, in patients taking semaglutide or tirzepatide, to warn of a small risk of developing severe acute pancreatitis

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Shortly thereafter, though, Petty started experiencing symptoms often associated with perimenopause, such as mood swings, anxiety, irregular periods and hot flashes

Understanding these factors helps clinicians and patients make informed decisions about medication use and implement appropriate monitoring strategies