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Microdosing therefore changes medication exposure, not mechanism

By activating these receptors, GLP-1 medications increase insulin secretion, reduce blood sugar levels, decrease glucagon release, slow down gastric emptying, and promote satiety, leading to reduced food intake and weight loss

Data analysis was carried out using the Ct method, and the fold RNA expression levels for Exe4 and Cas9 were calculated by normalizing with the Ct values of the internal control ( Gapdh ) and the saline-treated control groups

The use of agonists of GLP-1R has been demonstrated to be a good therapeutic approach against obesity and type 2 diabetes, by their ability to reach the CNS and modulate metabolic signals, converging in a common molecular mechanism

Modern agents like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound, which is technically a dual GLP-1/GIP agonist) are far more powerful

P = 0.183) [87]