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Food and Drug Administration Regulatory Orphan Drug and Fast Track designations

Patients were classified into drug treatment groups (semaglutide or tirzepatide vs other antidiabetic medications, including insulin, metformin, dipeptidyl-peptidase-4 inhibitors, sodium-glucose cotransporter-2 inhibitors, sulfonylureas, thiazolidinediones, and other GLP-1RAs) based on the first prescription in the study period (December 2017 to January 2023), which was the baseline, time zero, or index event

"In your mouth, there are receptors for GLP-1 on the nerves that carry taste information back to the brain," Munger says

However, in vitro studies have demonstrated that its metabolite, GLP-1(936), has protective effects in neuronal and microglial cell lines [41]

These often improve over time

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