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Complementary analyses using a Fine and Gray model and separate application of a cause specific hazard model with time varying inverse probability-of-death censoring weights yielded consistent results (supplementary figure S7)

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Semaglutide 2.4 mg, beyond robust weight reduction and improvements in surrogate markers of CVD, such as lipids and glucose, is now associated with benefits for hard CV outcomes CV death, nonfatal MI and nonfatal stroke. Additionally, while presenting cardiometabolic outcomes for retatrutide, Jastreboff said participants who received the 12 mg dose also experienced a mean 40% reduction in triglyceride levels and a mean 22% reduction in LDL cholesterol at 48 weeks, in addition to reductions in HbA1c and blood pressure