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This activity of GLP-1 has been demonstrated in both preclinical and clinical studies, and the results support the hypothesis that the GLP-1 pathway regulates the processes of alcohol use disorder (AUD)

[PubMed] 26.Scheen AJ, Lefbvre PJ

Inan M, Koyuncu A, Aydin C, Turan M, Gokgoz S, Sen M

Higher GLP-1 RA doses and, especially, the duration of treatment influenced the risk [61]

The preliminary cardiovascular safety data for DPP-4 inhibitors are promising, and, if the results of long-term cardiovascular studies demonstrate reductions in hard cardiovascular end points, then this may consolidate the position of the DPP-4 inhibitors as the second-line choice for combination with metformin

Appetite reduction often noticed within the first week