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Phase one of this four-phase trial has already concluded that TZP reduced systolic blood pressure (SBP) in 2,539 obese patients compared to placebos

J Biol Chem 289(33):2324623255 Kim J-H, Park G-Y, Bang SY, Park SY, Bae S-K, Kim Y (2014b) Crocin suppresses LPS-stimulated expression of inducible nitric oxide synthase by upregulation of heme oxygenase-1 via calcium/calmodulin-dependent protein kinase 4

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