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23 The other is made right inside the brain, mostly in preproglucagon neurons of the caudal hindbrain, specifically the nucleus tractus solitarius (NTS) and the adjacent intermediate reticular nucleus

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The interaction of obesityrelated hormones, adipocytokines, and inflammatory cytokines is hypothesized to stimulate antiapoptotic genes and impact cell migration, proliferation, and angiogenesis in a prooncogenic fashion [25, 26]