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doi: 10.3389/FENDO.2022.1033479 23 KoppKOGlotfeltyEJLiYGreigNH

10.1369/jhc.2008.951319 123 UssherJ

1,2 Mounjaros cardiovascular outcomes trial (SURMOUNT-MMO) is still running

Its a prescription injectable medication that you self-inject weekly

Red flag symptoms requiring urgent medical attention include: Severe, persistent abdominal pain, especially if radiating to the back and accompanied by vomiting (possible pancreatitis) Pain in the upper right abdomen, fever, or yellowing of the skin/eyes (possible gallbladder disease) Blood in vomit or stools Signs of severe dehydration (dark urine, dizziness, confusion) High fever (above 38C) accompanying digestive symptoms Unexplained weight loss beyond expected treatment effects Severe, persistent diarrhoea lasting more than 48 hours If you experience these red flag symptoms, call NHS 111 for advice or 999 in an emergency

Even in this setting, noninvasive imaging studies fail to detect 20% to 25% of insulinomas so that a negative study does not exclude the diagnosis (14)