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Combining weight loss medications, particularly agents with different mechanisms of action, introduces multiple safety concerns that extend beyond simple additive effects

We reported on three patients who received semaglutide from either compounding sources or a medical spa, says Amberly Johnson, director of the Utah Poison Control Center in Salt Lake City

Data were obtained from trials with subcutaneous and intravenous administration of semaglutide

Compounded semaglutide and tirzepatide became widely available during 2023 and 2024 shortages, but as commercial supply returned, most compounding of these specific molecules is no longer permitted

If you want to start at the lowest possible dose to minimize side effects, microdose semaglutide (Mochi or Shed) gives you a softer ramp

Focus on: Lean proteins (chicken, fish, tofu) Well-cooked vegetables White rice, pasta, or potatoes Bananas and other low-fibre fruits Plain yoghurt Avoid or limit foods that may exacerbate symptoms: High-fat, greasy, or fried foods (which slow digestion further) Spicy dishes Carbonated beverages Caffeine and alcohol Foods high in artificial sweeteners Stay well hydrated by drinking regularly throughout the day, aiming for 6-8 glasses of fluid daily