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Quality assessment The quality of evidence was assessed according to the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) guidelines [17]

[DOI] [PubMed] [Google Scholar] 228.Dalla Pellegrina C., Perbellini O., Scupoli M.T., Tomelleri C., Zanetti C., Zoccatelli G., Fusi M., Peruffo A., Rizzi C., Chignola R

On the other hand, metformin has milder risks, but there is a rare risk of lactic acidosis

& Nelson, C