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It occurs when the upper chambers of the heart (atria) beat out of sync with the lower chambers (ventricles)

The trial reported substantial weight reduction approximately 24% of body weight at the highest dose over 48 weeks and confirmed that gastrointestinal adverse events were the most frequently reported side effects

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doi: 10.1210/er.2016-1105 10 FeeldersRAPulgarSJKempelAPereiraAM

By week three or four, nausea becomes mild or disappears entirely for the majority of users, though some individuals may experience occasional mild queasiness for longer