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In addition to the well-known effects of GLP-1 and GLP-1 RA in improving insulin sensitivity and reducing body weight, at central levels, GLP-1 and GLP-1 RA might exert regulating effects on GhRH release, and on concomitant gonadotropin secretion, likely by activating the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons

GLP-1s are here to stay

Becker, Zoey

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Advances in cryo-electron microscopy imaging of receptor structures, and the ability to create dynamic models to understand how the receptors change shape, are now crucial parts of GPCR drug discovery that allow initial in silico screens

When electrolyte levels drop, these contractions can become weaker and less frequent