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GLP-1 medications may cause diarrhea (or frequent loose stools)

Liu W, Wang Z, Wang W, Wang Z, Xing Y, Hlscher C

Studies in rodents and humans indicate that GLP-1R is expressed in the renal vasculature [392,[766], [767], [768]]

Available options include GLP-1 receptor agonists such as semaglutide (2.4 mg weekly dose) and the dual GLP-1/GIP receptor agonist tirzepatide

Reduced Postprandial Concentrations of Intact Biologically Active Glucagon-Like Peptide 1 in Type 2 Diabetic Patients

JWU-A021 activates TRPA1 channels to promote Ca 2+ influx We next sought to identify the molecular target that mediates the action of JWU-A021 to stimulate an increase of [Ca 2+ ] i in STC-1 cells