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The Mediterranean dietary pattern has robust evidence for cardiovascular health and weight management sustainability, as recognized by the American Heart Association and Dietary Guidelines for Americans

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In addition, brainstem and hypothalamic GLP-1R activation, which are well established locations of pain modulation, could further contribute to the analgesic effects of these therapies [87]

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GLP-1 drugs like Wegovy and Zepbound have quickly emerged as some of the most effective tools to help treat obesity and its myriad comorbidities, and many pediatricians say that these drugs should also be used to help treat In 2023, the American Academy of Pediatrics updated its guidance for children and adolescents with obesity from a watchful waiting approach to include early treatment at the highest levels of intensity appropriate. This guidance supports expanding access to things like bariatric surgery and pharmacological interventions like GLP-1 drugs for patients where it is deemed appropriate

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