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For researchers interested in the comparison between tirzepatide and next-generation compounds like retatrutide, which adds a third receptor (GCG), our guide to retatrutide versus semaglutide provides useful context, as does our three-way comparison of semaglutide, tirzepatide, and retatrutide

This molecule, which uniquely targets the GIP, GLP-1, and Glucagon receptors, is showing groundbreaking efficacy: * Weight Loss: Participants on the highest dose achieved up to 24.2% average body weight loss at 48 weeks

clinicaltrials.gov/study/NCT0381156

10.1523/JNEUROSCI.0039-11.2011 [DOI] [PMC free article] [PubMed] [Google Scholar] Williams L

Early clinical studies have shown that mazdutide can induce significant weight loss alongside improvements in glycemic control and lipid metabolism

doi: 10.1038/302716a0 22 MojsovSHeinrichGWilsonIBRavazzolaMOrciLHabenerJF