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Of note, GLP-1 improvement of cardiovascular performance is, at least in part, independent of its ability to decrease body weight and to improve lipid metabolism, and GLP-1 may promote its cardiac effects via direct action at GLP-1R as well as indirect mechanisms independent of cardiac GLP-1R action [201,611,622]

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Key LC-MS Structural Confirmation Approaches High-resolution mass spectrometry is sensitive enough to detect single amino acid substitutions, truncated peptides, and post-translational modifications

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There are no ongoing or planned clinical studies addressing the role of tirzepatide in CKD