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Aims/hypothesis Metformin is the only approved oral agent for youth with type 2 diabetes but its mechanism of action remains controversial

Preclinical studies have confirmed that GIPRGLP1R coagonists improve several hallmarks of metabolic syndrome, such as obesity, hyperglycemia, and dyslipidemia

Prescription drugs continue to be a primary driver of employer-sponsored health care costs

Spontaneous reports do not represent unique exposed individuals and were not pooled with participant counts

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Explore the mechanisms, clinical applications, and future opportunities of GLP-1 receptor agonists in drug development and disease management.