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GLP-1, GIP & Inflammation: What These Medications Really Do and What They Dont Joshua Silva, MD Dec 5, 2025 7 min read Updated: Jan 27 Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD Quick Answer GLP-1 and GLP-1/GIP medications (such as semaglutide and tirzepatide ) can lower metabolic inflammation by improving insulin resistance, reducing visceral fat, and lowering inflammatory biomarkers such as C-reactive protein (CRP) ., They can also improve cardiometabolic risk markers (e.g., blood pressure) and, for tirzepatide, can improve atherogenic lipoprotein measures including apoB and triglyceride-rich lipoproteins in clinical research settings., They do not treat autoimmune diseases or fibromyalgia directly

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Hernandez combine extensive pediatric endocrine expertise with a concierge model designed to deliver highly personalized, relationship-centered care for every family

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People with pre-existing IBS If you have irritable bowel syndrome, particularly the diarrhea-predominant subtype (IBS-D), retatrutide can exacerbate your existing condition significantly

Melmed adds that if you have to switch insurance, be sure to give your doctors office plenty of advance notice in order to avoid gaps in your coverage