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GLP-1RA can also affect the process of skin aging through interaction with advanced glycation end products (AGEs) and RAGE (receptors of AGEs) activation
As it worsens, it can cause scarring, known as fibrosis, and can continue to advance to significant fibrosis or even cirrhosis, cancer, and the need for a liver transplant

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However, there was no significant difference in adverse CVEs or all-cause mortality when compared with those taking SGLT2 inhibitors

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