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GLP-1RA can also affect the process of skin aging through interaction with advanced glycation end products (AGEs) and RAGE (receptors of AGEs) activation

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As it worsens, it can cause scarring, known as fibrosis, and can continue to advance to significant fibrosis or even cirrhosis, cancer, and the need for a liver transplant

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However, there was no significant difference in adverse CVEs or all-cause mortality when compared with those taking SGLT2 inhibitors

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